| Thesis Name：Organic synthesis in water |
| Country：[CN] |
Usage：[Organic synthesis in water] |
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Reaction in aqueous media is one of important methods in organic synthesis,it can substitute some reaction in organic solvent. In this paper ,its specialty, application and researching progress are systematically introduced. |
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| Thesis Name：Synthesis and antitumor activities of hydroxyl-sub |
| Country：[CN] |
Usage：[Synthesis and antitumor activities of hydroxyl-sub] |
| Remarks： |
Hydroxyl-Substituted Macrocyclic Polyamines were synthesized, and two compounds and their metal complexes were found to be potential antitumor agents in antitumor activity assays against the BEL-7402 (human hepatocellular carcinoma ) cell line in vitro.
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| Thesis Name：Spectrophotometric determination of trace selenium |
| Country：[CN] |
Usage：[Spectrophotometric determination of trace selenium] |
| Remarks： |
A spectrophotometric method for the determination of selenium(IV) is described, based on the selenium-catalyzed oxidation of methyl orange with H2O2 in a nitric acid medium. As the redox reaction proceeds, the orange color of methyl orange is decolorized. The values of logA0/A show a good linear relationship with the amounts of selenium(here A0 and A stands for the absorbance of uncatalyzed reaction and catalyzed reaction, respectively ).The detection range is 18.8-65.7mg L-1 and the sensitivity is 0.876mg L-1.The method had been used to determine trace Se (IV) in high- Se tea with satisfactory results.
Keywords Catalytic kinetic spectrophotometry, Trace selenium, High-Se tea
Selenium is an essential trace element for animals and humans. It has wide biochemical and medical functions. There are many determination methods for selenium [1]. Spectrophotometric determination by catalytic kinetic method developed has been rapidly and used to analyze many kinds of elements [2,3]. But few methods have been reported for the determination of selenium [4-7].
This paper describes a new method for determination of Se(IV) based on its catalytic effects on the reduction reaction of methyl-orange with hydrogen peroxide in nitric acid medium. In addition, the mechanism of the catalytic reaction has been given.
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| Thesis Name：Study of protein binding of amlodipine and levamlo |
| Country：[CN] |
Usage：[Study of protein binding of amlodipine and levamlo] |
| Remarks： |
Study of protein binding of amlodipine and levamlodipine in human plasma albumin and bovine serum albumin solution by high performance capillary electrophoresis frontal analysis
The protein binding constants, binding sites and binding rate of Amlodipine and Levamlodipine in Human Plasma Albumin and Bovine Serum Albumin Solution were studied respectively by High performance capillary electrophoresis frontal analysis (HPCE/FA). The experiments were carried out by determining unbound drug concentration in drug-protein equilibrium solution in an uncoated fused silica capillary (40 cm × 50 mm i.d.; effective length 32 cm) for capillary electrophoresis under the following conditions: buffer, sodium phosphate solution (pH 7.4, ionic strength 0.17); UV detector, wavelength 214 nm; hydrostatic injection mode and the injection time 100 s, run voltage 10 kV. The unbound drug concentration was calculated from the plateau height of the profile with good linear relations, r>0.999 for both Amlodipine (N=6) and Levamlodipine(N=6), respectively. The determination of binding parameters was performed in accordance with Scatchard and Klotz equation. The reproducibility of the datum determined by HPCE/FA was confirmed by RSD (RSD < 0.39 %). The capillary electrophoresis frontal analysis provides an easy, accurate method for pharmacokinetics and pharmacodynamics study of the drug.
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| Thesis Name：Synthesis of side-chain polyamic acid under microw |
| Country：[CN] |
Usage：[Synthesis of side-chain polyamic acid under microw] |
| Remarks： |
P-p conjugated polyamic acid(PAA) was synthesized by the polycondensation of benzoguanamine (BGA) and pyromellitic dianhydride (PMDA) under microwave irradiation. Then PAA was grafted by lower molecular weight ploy(2-Hydroxyethyl Acrylate)(PHEA) to the main chain. The effect of the amount of catalyst, the molar ratios of PAA and PHEA structural units and the molecular weight of PHEA on the intrinsic viscosity and the graft degree were investigated. Thin films of the graft polymers were obtained by spinning-coat method. The film quality was improved obviously by graft modification. The third-order nonlinear optical (NLO) responses were probed by degenerated four wave mixing(DFWM) technique. The results show that the third-order NLO coefficient of the polymer films is larger than that of the polymer solutions. |
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| Thesis Name：Study on the retention behavior of sulfur compound |
| Country：[CN] |
Usage：[Study on the retention behavior of sulfur compound] |
| Remarks： |
Based on the reversed phase ion-pair chromatography, the retention behaviour of thiourea, polysulfide, ammonium sulfide and ammonium thiocyanate were discussed under different conditions such as ion pair reagent and its concentration, ion intensity and organic reagent. It was testified that the concentration of ion pair reagent, pH and the volume ratio of tetramethylene-oxide in mobile phase played important roles in the retention behavior of ammonium sulfide and ammonium thiocyanate. The best analytical results were obtained by using a C18 column with a mobile phase comprising a 20:79:1 (% v/v) mixture of methanol-water-tetramethylene-oxide, pH 6.64, containing 3.0 mmolL-1 ammonium tetrabutyl bromide and 6 mmolL-1 KH2PO4-K2HPO4 buffer. Column temperature and detection wave were controlled at 25ºC and 220nm, respectively. Linearity of the working curve was investigated with correlation coefficients of 0.9989-0.9999, and the relative standard deviation was below 4.9%. The proposed method had been successfully used in the samples determination.
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| Thesis Name：Preparation of activated rough electrode in KMnO4 |
| Country：[CN] |
Usage：[the electrocatalytic oxidation of ascorbic acid] |
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The preparation of activated rough glass carbon electrode (ARE) in KMnO4 solution and its electrocatalytic oxidation for Ascorbic acid (AA) were studied. The ARE showed higher electrochemical activity of ascorbic acid and its mechanism of catalysis was studied. In the buffer solution of pH 5.0, a sensitive oxidation peak of AA was observed at 0.17V at ARE, which is 500mV more negative than on flat glassy carbon electrode. The oxidation peak of AA is linear with its concentration from 4×10-6mol/L to 8×10-4mol/L in the pH 5.0 buffer solution (R=0.9993), Detectian limit of it reached 1×10-6mol/L. ARE had been successfully applied to the determination of AA in medicament sample.
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| Thesis Name：Preparation of nanosolid superacid S2O82-/ZrO2 and |
| Country：[CN] |
Usage：[Preparation of nanosolid superacid] |
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The synthesis of borneolacetate with nano solid superacid S2O82-/ZrO2 as catalyst was proposed in this paper. The preparation of catalyst and esterification condition were studied. The results showed that catalyst acid strength was-12.70
Keywords nanosolid superacid, synthesis, borneolacetate
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| Thesis Name：Global geometry optimization of Na+(H2O)m clusters |
| Country：[CN] |
Usage：[Global geometry optimization] |
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A hybrid algorithm, based on genetic algorithm (GA), fast simulated annealing (FSA) and conjugated gradient algorithm (CGA) was proposed and used to optimize the structure of Na+(H2O)m (m=1-11) clusters. The empirical potential energy functions employed here included SPC, TIP, TIP3P, TIP4P and TIPS2. The optimized structure of Na+(H2O)m clusters by using these different potential energy functions were found to share the same configurations. |
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| Thesis Name：Nucleation and growth of CaCO3 crystals on PDAC/PS |
| Country：[CN] |
Usage：[Nucleation] |
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Fabrication of biomimetic laminated composite by mimicking the cyclical matrix control processes to form the highly structured Mollusca nacre is presented in this paper. (PDAC/PSS)n self-assembled multilayers were built-up through alternative absorption of polycation and polyanion to a substrate as matrices and their chemical structure were characterized by UV-Vis absorption spectra. And then the deposition of CaCO3 took place on the multilayers by dipping them into a supersaturated CaCO3 solution. The morphology and the structure of the CaCO3 crystals were characterized by SEM and X ray diffraction respectively. With (PDAC/PSS)15 the hexagonal crystals of CaCO3 with the pellet size of 10-20mm, which were very similar to the crystals existed in nacre, was obtained after 10 hr deposition. |
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