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| Research Domain：Biochemistry |
Country：[CN] |
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Biochemistry |
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| Research Domain：Chemical Technology |
Country：[CN] |
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Focuses in the FIT Micro-Energy Technology:
- component development for batteries
- synthesis and characterisation of battery materials
- development and construction of prototypes for special batteries
- characterisation of primary and secondary batteries in a climate chamber from -70 to +150°C
- vacuum oven, inert gas oven and high temperature oven
- simulation of environmental impacts in a special chamber
- leak tests in a climate chamber
- inert gas workplace
- screen printing device
- heatable 100 t press
- cyclic voltammetry
- impedence spectroscopy
- differential electrochemical mass spectroscopy
- infrared and RAMAN spectroscopy
- light microscopy
- x-ray diffraction
- thermal analyses (DSC,TMA)
- particle size analysis, BET |
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| Research Domain：Silicat |
Country：[CN] |
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Focuses in the FIT Micro-Energy Technology:
- multi-functionality of application and manufacture including safety aspects on the basis of chemical design
- polymer electrolyte, separators,binding materials for electrodes on the basis of Sol-Gel and hybrid polymers (ORMOCERen) for secondary batteries and supercapacitors.Construction through coating and foil technology
- micro-structured PEMs for micro-fuel cells (focus on DMFC and similar)
- multi-layer membranes involving catalytic particles
- capsulation of batteries |
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| Research Domain：material science and technology |
Country：[CN] |
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Scope of Activities
Basic research related to material science and technology, and research and development of related research and intellectual infrastructure.
Encouragement of practical application of R&D results, including transfer to the private sector.
Shared use of institute facilities and equipment with researchers from other institutions.
Training and development of researchers and technical people. |
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| Research Domain：Physical and Chemical |
Country：[CN] |
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The mission of RIKEN is to conduct comprehensive research in science and technology (excluding only the humanities and social sciences) as provided for under the "RIKEN Law," and to publicly disseminate the results of its scientific research and technological developments. RIKEN carries out high level experimental and research work in a wide range of fields, including physics, chemistry, medical science, biology, and engineering, covering the entire range from basic research to practical application.
RIKEN was first organized in 1917 as a private research foundation, and reorganized in 2003 as an independent administrative institution under the Ministry of Education, Culture, Sports, Science and Technology. |
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| Research Domain：natural products total synthesis, synthetic methods development, and the design and application of new transition metal catalyzed reactions |
Country：[CN] |
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Our research group is involved in natural products total synthesis, synthetic methods development, and the design and application of new transition metal catalyzed reactions. The details of some ongoing research research projects are given below. Please see our publications page for details of this work.
Synthetic Approaches to the Eunicellin Diterpenes
The eunicellin diterpenes are a large family of biologically active natural products which have in common a bicyclo[8.4.0]tetradecane ring system, but which differ in stereochemistry and in the degree and pattern of oxidation. Eleutherobin, for example, has been found to have potent anti-cancer activity against a variety of tumor cell lines. It stabilizes microtubules and thus suppresses cell division, a mechanism of action it shares with taxol. Sclerophytin-A exhibits cytotoxicity at 1 ng/ml in the L1210 leukemia cell line. Astrogorgin inhibits cell division in fertilized starfish eggs. Other eunicellin diterpenes such as massileunicellin-I have not been assayed for biological activity. We have embarked on a long term study directed toward the synthesis of several members of the eunicellin diterpene family. The goal is to develop strategies and methods that will result in general and flexible approaches to these targets as well as to simplified analogs. We are exploring two general approaches to the eunicellin diterpenes: the Ireland-Claisen rearrangement and the cycloaldol reaction.
Our research group is involved in natural products total synthesis, synthetic methods development, and the design and application of new transition metal catalyzed reactions. The details of some ongoing research research projects are given below. Please see our publications page for details of this work.
Synthetic Approaches to the Eunicellin Diterpenes
The eunicellin diterpenes are a large family of biologically active natural products which have in common a bicyclo[8.4.0]tetradecane ring system, but which differ in stereochemistry and in the degree and pattern of oxidation. Eleutherobin, for example, has been found to have potent anti-cancer activity against a variety of tumor cell lines. It stabilizes microtubules and thus suppresses cell division, a mechanism of action it shares with taxol. Sclerophytin-A exhibits cytotoxicity at 1 ng/ml in the L1210 leukemia cell line. Astrogorgin inhibits cell division in fertilized starfish eggs. Other eunicellin diterpenes such as massileunicellin-I have not been assayed for biological activity. We have embarked on a long term study directed toward the synthesis of several members of the eunicellin diterpene family. The goal is to develop strategies and methods that will result in general and flexible approaches to these targets as well as to simplified analogs. We are exploring two general approaches to the eunicellin diterpenes: the Ireland-Claisen rearrangement and the cycloaldol reaction.
Most of the eunicellin diterpenes possess a hydroisobenzofuran core with a bridging oxonane ring at C2 and C9. We have found that a novel cycloaldol reaction enables the rapid assembly of the isobenzofuran bicycle with excellent diastereoselectivity. An initial intermolecular aldol reaction between (S)-carvone and methacrolein establishes the desired stereochemistry at C1, C2 and C14. Etherification and cycloaldolization affords the isobenzofuran. The C9 stereocenter is formed with complete diastereoselectivity. Thus four of the stereocenters present in the natural products can be installed in only 3 steps from (S)-carvone. We are employing the cycloaldol reaction in the synthesis of the highly oxidized massileunicellins as well as simplified bicyclic analogs for use in high throughput synthesis. |
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| Research Domain：biochemical |
Country：[CN] |
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*Peptide synthesis
*Oligo synthesis
*Amino acid analysis
*Protein sequencing
*Mass spectrometry |
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| Research Domain：life sciences |
Country：[CN] |
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The National Institute of Biological Sciences, Beijing (NIBS, Beijing) was established to advance the frontier of basic research in the life sciences in China. Founded in 2003 as part of a strategic government initiative to further national development of science and technology, NIBS aims to become a first rate, internationally competitive research institution. Its faculty will educate future generations of life scientists and explore a new model for operating scientific institutions in China.
The major components of NIBS are its research laboratories and core facilities. The Principal Investigators (PIs) are selected from a highly competitive international applicant pool. Upon invitation by the NIBS Director, a Selection Committee evaluates the applicants and recommends candidates for appointment, and the Director makes the final decision. A PI shall serve for 5 years and the reappointment is contingent upon academic evaluations by the SAB and the Director’s evaluation of the PI’s research and contribution to the future development of NIBS. Heads of the core facility will be appointed by the Director.
NIBS is backed by the full support of the Chinese leadership. The Board of Trustees (BOT) is responsible for institute policy and consists of representatives from eight agencies, including the Ministry of Science and Technology (MOST), National Development and Reform Commission (NDRC), the Ministry of Education (MOE), the Ministry of Health (MOH), the Chinese Academy of Sciences (CAS), the National Natural Science Foundation of China (NNSFC), and the Beijing Municipal Government. MOST and the Beijing Municipal Government are primarily responsible for overseeing the operation of NIBS and provide the major sources of funding. The term for each BOT member is 3 years and its members may be reappointed.
The Director is responsible for the daily operations of NIBS under the leadership of the BOT. The BOT shall further select well-known scientists to serve on a Scientific Advisory Board (SAB). The SAB is consulted on issues related to PI appointment and research development. Its mission is also to select and advise the Director and provide support as needed to the BOT. The initial term of appointment to the SAB is three years, and its members may be reappointed.
The appointment of Director of NIBS is made following a rigorous international search process. After the BOT issues a call for applications, the SAB evaluates submissions and makes recommendations to the BOT, which makes the final offer. The Director shall be a well-established, internationally known scientist with distinguished research achievements in the life sciences. The Director shall serve 5 years and may be re-appointed. In April 2003, the BOT accepted the recommendation of the SAB and appointed Dr. Xiaodong Wang, a member of the U.S. National Academy of Sciences and a biochemist and cell biologist from the University of Texas Southwestern Medical Center, and Dr. Xingwang Deng, a plant biologist from Yale University, as Co-Directors of NIBS. |
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| Research Domain：new chemical materials and chemical engineering processes |
Country：[CN] |
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Hubei Research Institute of Chemistry (HRIC), is not only a comprehensive scientific institute also a new and high-tech enterprise. It is located in the middle and lower reaches of the Yangtze River in Wuhan, China. It is staffed with 219 persons, includes 41 senior researchers, 3 national experts, 7 provincial experts, and 24 supported by state government subsidy.
The Institute specializes in the fields of new chemical materials and chemical engineering processes. These include : catalysts for the synthetic ammonia industry and for gas purification, chemical materials for a range of industries and fields, including optical communication, textiles industry, the information and electronic industry, mechanical and electrical insulation, functional inorganic and organic synthetic compounds, agricultural chemicals, and so on.
According to the statistics of 1995 by the Ministry of Sci & Tech of P.R.C, the Institute ranked 141st compared in the comprehensive strength and 9th compared in operating effect in China. The Ministry of Sci & Tech of P.R.C designated it as Advanced New and High-tech Enterprise.
High-level achievements, first-class talents, high-tech industry, and great social and economic benefits, is our goal. The Institute devotes its efforts to scientific and technological advancement, and the commercialization, industrialization, and internationalization of new chemical materials and new chemical processes. HRIC is ready to carry out technology exchange and cooperation in various forms with customers and with counterparts in the relevant industries. |
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| Research Domain：synthetic organic chemistry, bioorganic chemistry, physical organic chemistry, natural products chemistry and organic materials chemistry |
Country：[CN] |
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Founded in 1987, the State Key Laboratory of Applied Organic Chemistry (abbreviated as SKLAOC) at Lanzhou University is one of the first state key laboratories ratified by the State Planning Commission of China. With continuous effort in years, the SKLAOC has become an important national center for scientific research in the area of organic chemistry and related disciplines. Nowadays, the Laboratory consists of 260 members – 1 academician of Chinese Science Academy, 28 professors, 40 support and professional staff, 80 graduate and 150 undergraduate students – organized into 16 research groups. The SKLAOC was headed by Academician You-Cheng Liu and later by Prof. Zhong-Li Liu. Since 2001, Prof. Yong-Qiang Tu has been directing the Laboratory. The main research in the SKLAOC focuses on synthetic organic chemistry, bioorganic chemistry, physical organic chemistry, natural products chemistry and organic materials chemistry. The Laboratory research is sponsored by the Department of Science and Technology, the National Natural Science Foundation of China, the Department of Education and other governmental and industrial organizations. More than 150 papers are published annually, 80 % of which appear in prestigious international journals. Scientific talks including invited lectures have been presented frequently in national/international conferences and symposia. Serving as a center for scientific exchange, the Laboratory has cooperation projects with numerous institutions all over the world. Young organic chemists are well educated and trained in the SKLAOC and have great opportunity to further working in famous institutions such as the Department of Chemistry at Harvard University and the Scripps Research Institute. Several young chemists from the SKLAOC joined the research groups of Prof. E. J. Corey, Prof. K. C. Nicolaou, Prof. D. H. R. Barton and so on. Additionally, more than ten scholars from the SKLAOC received the Alexander von Humboldt fellowships.
Among the facilities available at the SKLAOC are Varian Inova 600, Varian Mercury 400 and Mercury 300 NMR spectrometers equipped with various double- and triple-resonance probes, Bruker Avance DRX-200 wide-bore NMR spectrometer equipped with photo-CIDNP and in vivo micro-imaging probes, Bruker Avance 400 wide-bore solid-state NMR spectrometer equipped with double- and triple-resonance probes, FT-ICR mass spectrometer with ESI, APCI, EI,CI and SIMS ion sources and connected to HPLC, HP 5988 GC mass spectrometer, Jasco J-810 and J-20C CD spectropolarimeters, Princeton PAR-170 electrochemical systems and a variety of GC, GC-MS, HPLC, IR and UV spectrometers. Also available are: VG ZAB HS high resolution mass spectrometer with GC, Bruker ER 200D EPR spectrometer, Enraf-Noinus CAD 4 X-ray diffractometer, Nicolet 170 SX IR spectrometer with GC and Spex DM 103 laser Raman spectrometer. |
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