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| Research Domain：catalytic chemistry and organic catalysis |
Country：[CN] |
| Research Production： |
Research interests mainly focus on catalytic chemistry and organic catalysis, particularly experienced on the catalytic functionalization of hydrocarbon. Catalytic selective oxidation is one of my most desirable reactions with molecular oxygen, which remains an attractive subject and challenges both academic research and industrial process, such as the oxidation of benzene to phenol, cyclohexane to cyclohexanone, toluene to benzyl alcohol and benzaldehyde.
Catalytic activation of C-H and C-X bonds with environmental- benigned processes is a current interest research area. Other research fields are including selective hydrogenation, hydrodechlorination and halogenation. For examples, the processes of hydrogenation of benzene to cyclohexene, dechlorination of PCBs, process development of 2-chloro-5-trifluoromethyl-pyridine.
Up to now, more than 100 papers have been published and more than 30 patents were issued. |
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| Research Domain：asymmetric homogeneous coordination catalysis and its applications |
Country：[CN] |
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The central theme of research is asymmetric homogeneous coordination catalysis and its applications. One major focus of my research is to develop the novel synthetic routes and process technologies for specialty fine chemicals such as fluorine -containing, heterocycle and chiral structures. The ultimate goal of the research and development should lead to the commercialization of some unique fine chemicals.
In the field of asymmetric catalysis, three classes of ligands such as the chiral Schiff bases, the chiral ferrocenes, and the carbohydrate derivatives were designed and synthesized, a series of transition metal complexes were characterized and examined for their catalytic activities and selectivities for the asymmetric reactions such as cyclopropanation, hydrogenation, epoxidation, the kinetic resolution of epoxides, allylic substitution, and transfer hydrogenation etc. Several chiral catalyst systems based on these metal complexes have been found their direct applications to chiral pharmaceuticals, pesticides and their intermediates. More than twenty scientific papers in the fields of asymmetric catalysis and related subjects have been published.
The studies of these novel asymmetric catalysts have led to the development and commercialization of close to ten fine chemicals, exemplified by technically challenging deltamethrin, the new mode of action pesticide. Fifteen new invention patent applications have been filed in China. |
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| Research Domain：undamental study and applied exploration of novel opto-functional materials |
Country：[CN] |
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Yao has been engaging in the fundamental study and applied exploration of novel opto-functional materials. Yao made great achievements and breakthrough on the size-tunable photophysical and photochemical properties of organic nanoparticles, photochromism of inorganic and organic/inorganic hybrid materials, for which he was, conferred the “ Second-class prize from the National Awards for Natural Science ” in 2004. Yao has been honored the "Excellent Supervisor Award” of CAS for several times. He got the award of the “National Science Fund for Distinguished Young Scholars” in 1995. As the group leader, the work on “Design, preparation and characterization of novel opto-functional materials” was funded “Science Fund for Creative Research Groups” in 2003. He has authored, or coauthored 148 scientific papers in international journals such as Nature , J.Am.Chem.Soc ., Angew.Chem.Int.Ed. , Adv.Mater. , and so on (cited 560 times by others). He also coauthored a book and a translated book. |
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| Research Domain：Colloid and Interface |
Country：[CN] |
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Research Professor of Institute of Chemistry, Elected as CAS Academician in 2001, Graduated from Chemistry Department of Nanjing University majoring in Colloid Chemistry in 1953, Graduated from Institute of Physical Chemistry in Academy of Sciences of USSR from 1956 to 1960, and got Ph.D. Degree in 1960 in Moscow . His main research area is Colloid and Interface Science. In the early days of his research, he studied the relationship of polymerization rate of silicic acid and pH under the supervise of Academician Dai Anbang and has received the 2nd National Natural Science Award; In 1960 th to 1970 th , he took part in the research and development work on photographic film for remote-sensing reconnaissance; In 1980 th he was dealing with rheology and stabilization of disperse system, such as high loaded coal water slurry as well as surface rheology in enhanced oil recovery and solved a series of difficult tasks ; He developed some useful home made equipment for the surface rheology investigation, proving the closing relationship between the stability of emulsion and the surface viscosity. From 1986, his main interest has focused in Biomimetic films; Biosensor and other molecular organized assemblies, promoted and organized the committee of “organized molecular assemblies” in Chinese Chemical Society. He has been made a lot of contributions in the biomimetic membrane, such as enzymatic membrane, artificial vision-mimetic membrane. Color changeable vesicle biosensor, DNA sensor as well as the nanometer particles preparation and their application in biological system. His work on the detection of E-coli by color changeable vesicle has been published in J. Amer. Chem. Soc. and other famous journals. He is the author/translator/editor of five books and 10 patents as well as 198 scientific papers. He is the international editor of the Russian journal "Colloid Journal" (Eng. Edition) and editor of 4 Chinese journals. |
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| Research Domain：COMPLEX ADAPTIVE AGENT-BASED SYSTEMS,SUPERVISION OF MANUFACTURING PROCESS OPERATIONS,MODELING AND SIMULATION OF BIOMEDICAL SYSTEMS |
Country：[CN] |
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Hierarchical multi-agent systems for modeling, supervision, and control of distributed complex adaptive systems;
Techniques for supervision of manufacturing process operations: Multivariable process monitoring, performance assessment, fault diagnosis, and fault-tolerant control;
Development of metabolic pathways and dynamic models of insulin secretion and utilization and simulation of biomedical systems
Awards and Honors:
Ernst W. Thiele Award, Chicago Section of AIChE, 2003
W. M. Langdon Award for Excellence in Teaching, 1996
ASA/NSF/NIST Senior Research Fellow, 1992-1993
W. M. Langdon Award for Excellence in Teaching, 1987 |
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| Research Domain：analytical chemistry and its application in environmental and food safety, as well as the related biochemistry |
Country：[CN] |
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Research interests focus on analytical chemistry and its application in environmental and food safety, as well as the related biochemistry. I pay attention to the development of analytical procedures for the extraction and detection of pollutants, such as pesticide residuals and persistent organic pollutants, in foodstuffs. To establish bio-screening analytical methods for the determination of important pollutants and the bioassay-guided fractionation of natural products by using cell and enzyme is my particular interests. In fact, food safety is heavily depended on its production environments since pollutants are concentrated through food chain. Additionally, constraining from environment to life used as foodstuff can result in the unexpected components. I thus investigate the effect of these factors on food safety and develop the corresponding evaluation measurements. Meanwhile, I also intend to develop some techniques to remedy the polluted environmental elements, especially for the soil polluted with organic compounds, by combining chemical and biological techniques (chemically enhanced bioremediation). |
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| Research Domain：development of miniaturized GC and LC instrumentation |
Country：[CN] |
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Research Interests
His major interests are development of miniaturized GC and LC instrumentation, capillary LC and CEC columns, coupling of capillary LC with CGC, water sample pre-treatment and process analyzers for industry. |
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| Research Domain：fundamental study and applied exploration of novel opto-functional materials |
Country：[CN] |
| Research Production： |
Yao has been engaging in the fundamental study and applied exploration of novel opto-functional materials. Yao made great achievements and breakthrough on the size-tunable photophysical and photochemical properties of organic nanoparticles, photochromism of inorganic and organic/inorganic hybrid materials, for which he was, conferred the “ Second-class prize from the National Awards for Natural Science ” in 2004. Yao has been honored the "Excellent Supervisor Award” of CAS for several times. He got the award of the “National Science Fund for Distinguished Young Scholars” in 1995. As the group leader, the work on “Design, preparation and characterization of novel opto-functional materials” was funded “Science Fund for Creative Research Groups” in 2003. He has authored, or coauthored 148 scientific papers in international journals such as Nature , J.Am.Chem.Soc ., Angew.Chem.Int.Ed. , Adv.Mater. , and so on (cited 560 times by others). He also coauthored a book and a translated book. |
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| Research Domain：Colloid and Interface Chemist. |
Country：[CN] |
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Colloid and Interface Chemist. Born in Shanghai in 1933, native place is Fujian Province . Research Professor of Institute of Chemistry, Elected as CAS Academician in 2001, Graduated from Chemistry Department of Nanjing University majoring in Colloid Chemistry in 1953, Graduated from Institute of Physical Chemistry in Academy of Sciences of USSR from 1956 to 1960, and got Ph.D. Degree in 1960 in Moscow . His main research area is Colloid and Interface Science. In the early days of his research, he studied the relationship of polymerization rate of silicic acid and pH under the supervise of Academician Dai Anbang and has received the 2nd National Natural Science Award; In 1960 th to 1970 th , he took part in the research and development work on photographic film for remote-sensing reconnaissance; In 1980 th he was dealing with rheology and stabilization of disperse system, such as high loaded coal water slurry as well as surface rheology in enhanced oil recovery and solved a series of difficult tasks ; He developed some useful home made equipment for the surface rheology investigation, proving the closing relationship between the stability of emulsion and the surface viscosity. From 1986, his main interest has focused in Biomimetic films; Biosensor and other molecular organized assemblies, promoted and organized the committee of “organized molecular assemblies” in Chinese Chemical Society. He has been made a lot of contributions in the biomimetic membrane, such as enzymatic membrane, artificial vision-mimetic membrane. Color changeable vesicle biosensor, DNA sensor as well as the nanometer particles preparation and their application in biological system. His work on the detection of E-coli by color changeable vesicle has been published in J. Amer. Chem. Soc. and other famous journals. He is the author/translator/editor of five books and 10 patents as well as 198 scientific papers. He is the international editor of the Russian journal "Colloid Journal" (Eng. Edition) and editor of 4 Chinese journals. |
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| Research Domain：Chemical Biology |
Country：[CN] |
| Research Production： |
1. Engineering Membrane Channels and Pores
Pore-forming proteins are being engineered for applications in biotechnology. Our main focus is on a-hemolysin, a bacterial toxin that forms a heptameric transmembrane pore of known three-dimensional structure. By using genetic engineering and targeted chemical modification, pores are being made with diverse functional properties. In addition, transmembrane b barrels are being engineered by combining fragments from various bacterial toxins and porins, as well as polypeptide segments designed de novo. The new molecules are finding applications in several areas including drug delivery and the construction of biosensors. These efforts require an excellent basic understanding of membrane protein assembly and function, and we are continuing our work in this area, in particular by using single molecule approaches.
2. High-Throughput Screening with Membrane Proteins
Recent advances have demonstrated that large fractions of prokaryotic and eukaryotic genomes encode membrane proteins. Therefore, there is a pressing need for high-throughput methods to investigate the assembly and functional properties of these polypeptides. By collaborating with laboratories conversant with chip technology, we are developing approaches for the parallel processing of hundreds of membrane samples. Eventually, the approach will yield procedures for refolding membrane proteins and for forming three-dimensional crystals from them. If functional membrane proteins can be obtained on chips, they will be used for high-throughput assays in drug discovery and as a basis for making biosensor arrays.
3. Biomolecular Materials by Design
The design and synthesis of biomolecular materials is a rapidly growing interdisciplinary area, in which the properties of molecules found in nature are mimicked or extended to produce materials with unusual properties. An additional goal is to manufacture and dispose of materials by environmentally benign methods of low energy cost. The heterologous expression of protein-based materials is an attractive option. We are exploring this and related approaches for making materials that form porous sheets, fibers, adhesives and elastomers. For example, we have initiated engineering studies on S layers, the robust porous proteinaceous envelopes that surround many bacterial cells. One goal is to obtain porous monolayers containing molecular switches, for use in biosensors. In another example, we are engineering abductin, a protein found in the highly elastomeric inner hinge ligaments of bivalve mollusks. The project will yield elastomers for use thin films, and in microfluidic and energy storage devices.
4. Caged Peptides and Proteins for Signal Transduction Research
The use of "caged" reagents allows the photogeneration of molecules on or in cells with precise spatial and temporal control. In signal transduction research, effectors and inhibitors can be released at known sites, in defined doses, and at predetermined times. We are using a variety of photoremovable protecting groups to cage peptides and proteins for studies of cell signaling. One tactic has been to derivatize proteins engineered to contain single cysteines at key positions. In this way, a photoactivatable catalytic subunit of protein kinase A has been made. The activities of many cell signaling proteins are modulated by phosphorylation. Therefore, we are also examining peptides and proteins modified on the sulfur atom of thiophosphoryl groups. |
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